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           Vitamin E

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Vitamin E: 

Vitamin E: Vitamin E is an antioxidant. It also has antithrombotic activity, and may have anti-atherogenic, anti-viral, neuroprotective and immune-boosting activity. Its precise mechanism(s) of action  is unknown. Deficiency results in sensory peripheral neuropathy, myopathy and cerebellar ataxia. It is a fat-soluble vitamin, and diseases that cause fat malabsorption (such as Crohn's, pancreatitis, and cystic fibrosis) may result in Vitamin E deficiency. It should be noted that in  synthetic Vitamin E (dl-alpha-tocopheryl) half of the content is not usable by the body, but still has anti-clotting activity! Look for natural Vitamin E. Vitamin E should be stopped before surgery.

Toxicity: There are no reports of drug overdosage with Vitamin E.

Tolerable Upper Limits: Children 1-3,200 mg; 4-8, 300 mg; 9-13, 600 mg; 14-18children and pregnant or lactating children, 800 mg; Adults, including pregnant and lactating women 1,000 mg.

Drug Interactions: Anticonvulsants, cholestyramine, colestipol, INH, mineral oil, neomycin,orlistat and sucralfate may decrease Vitamin E absorption or impair utilization. High doses of Vitamin E may enhance the effects of antiplatelet drugs and the anticoagulant response to warfarin. Some herbs, such as garlic and ginko, possess antithrombotic effect and Vitamin E may enhance that effect as well. Vitamin C may spare Vitamin E after it has been oxidized. Selenium may enhanve Vitamin E's effects.


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Last modified: June 04, 2005