(Sponsored by Medical Utilization Management, L.L.C.)
Riboflavin (Vitamin B2): Riboflavin plays a vital role in energy production. Flavoenzymes are key in cellular respiration, acting as hydrogen receptors in mitochondrial electron transport. Riboflavin deficiency is known as pelegra, usually found in those who do not consume a diet rich in organ meats, dairy, leafy greens and whole grains. It is seen in the elderly, alcoholics and those with chronic liver disease and those on total parenteral nutrition. Deficiency may be associated with severe lactic acidosis, especially in HIV patients on triple antibiotics. It also functions as an antioxidant. Riboflavin absorption is decreased in hyperthyroidism.
Toxicity: Rare cases of diarrhea and polyurea in patients on 400 mg/day for migraines have been reported.
Tolerable Upper Limits: Not established.
Drug Interactions: Cholestyramine, Colestapol, oral contraceptives and probenecid may interfere with riboflavin absorption. Chlorpromazine, doxorubicin, and tricyclic antidepressants may interfere with its action.
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