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           Pyrodoxine (B6)

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Pyrodoxine (Vitamin B6): Vitamin B6 (pyridoxine, pyridoxal and pyridoxamine) is involved in a wide range of biochemical reactions, including the synthesis of DNA and RNA, formation of blood and nerve tissue, neurotransmittors, and amino acids, including homocysteine. In one study, one-third of elderly patients were found to be boarderline deficient in B6; those with uremia and HIV are also at increased risk.

Toxicity: There is concern for development off sensory neuropathy in dosages exceeding 500 mg/day.

Tolerable Upper Limits: 

Children: 0-12 mos unknown; 1-3 yrs 30 mg/day; 4-8 yrs 40 mg/day; 9-13 60 mg/day;14-18 1.2 mg/day

Adults: 100 mg/day

Pregnancy and lactation: 14-18 yrs 80 mg/day;19 yrs and older 100 mg/day

Drug Interactions: Carbamazepam, cycloserine, theophylline, ethionamide, isoniazid (INH), oral contraceptives, valproic acid, HCTZ, hydralazine and alcohol may all increase vitamin B6 requirements. High doses of B6 may lower drug levels of dilantin, negate the effects of patients taking levdopa without carbidopa, and inactivate phenelzine.



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Last modified: June 04, 2005